Nitrazepam has been associated with severe hepatic disorders, comparable to other nitrobenzodiazepines. Nitrobenzodiazepines for instance nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more poisonous towards the liver than other benzodiazepines as They're metabolically activated by CYP3A4 which can result in cytotoxicity.Nitrazep